SPIN90 modulates the architecture of lamellipodial actin in an ARPC5L dependent fashion.
LuYan Cao*, Angika Basant, Miroslav Mladenov, Naoko Kogata, Antoine Jegou, Guillaume Romet-Lemonne, Sophie Brasselet, Manos Mavrakis and Michael Way*. * co-corresponding BioRxiv. https://doi.org/10.64898/2025.12.01.691495
In situ cryo-electron tomography of vaccinia virus exit from infected cells
Miguel Hernandez-Gonzalez, Andrea Nans, Thomas Calcraft, Peter B Rosenthal and Michael Way.
BioRxiv https://doi.org/10.1101/2025.08.20.671218
The actomyosin cortex controls t-tubule remodeling in muscle.
Ana Raquel Pereira, Ana da Rosa Soares, Silvia Di Francescantonio, Tianyang Liu, Filomena A. Carvalho, Josie Liane Ferreira, Graciano Leal, Inês Faleiro, Naoko Kogata, Nuno C. Santos, Michael Way, Carolyn A. Moores and Edgar R. Gomes.
BioRxiv. https://doi.org/10.1101/2024.08.13.607563
Enhancing the efficiency of oncolytic vaccinia virus for ovarian cancer treatment.
Stephanie Drymiotou, Christophe J. Queval, Katherine E. Tyson, Lesley A. Sheach, Antonio Postigo, Ilaria Dalla Rosa, Michael Howell, Iain A. McNeish* and Michael Way*. Molecular Therapy Oncology – First published online Dec 3rd 2025. * co-corresponding
Branched actin networks mediate macrophage-dependent host microbiota homeostasis.
Luiz Ricardo C. Vasconcellos#, Shaina Chor Mei Huang#, Alejandro Suarez-Bonnet, Simon Priestnall, Sunita Varsani-Brown, Matthew L. Winder, Kathleen Shah, Naoko Kogata, Brigitta Stockinger and Michael Way. Science 390:728-734. 2025 # co-first author
Arp2/3-mediated bidirectional actin assembly by SPIN90 dimers in metazoans.
Tianyang Liu, Luyan Cao, Miroslav Mladenov, Guillaume Romet-Lemonne, Michael Way* and Carolyn A. Moores*.
Nature Structural & Molecular Biology. 32:2262–2271. 2025 * co-corresponding
Non-redundant roles of topoisomerase 2α and 2β in the cytosolic replication of vaccinia virus.
Ilaria Dalla Rosa* and Michael Way* Nucleic Acid Research 53:gkaf566. 2025 * co-corresponding.
Multi-omics characterization of the monkeypox virus infection.
Yiqi Huang, Valter Bergant, Vincent Grass, Quirin Emslander, M Sabri Hamad, Philipp Hubel, Julia Mergner, Antonio Piras, Karsten Krey, Alexander Henrici, Rupert Öllinger, Yonas M Tesfamariam, Ilaria Dalla Rosa, Till Bunse, Gerd Sutter, Gregor Ebert, Florian I Schmidt, Michael Way, Roland Rad, Andrew G Bowie, Ulrike Protzer, Andreas Pichlmair.
Nature Comms 15:6778. 2024
CK-666 and CK-869 differentially inhibit Arp2/3 iso-complexes.
LuYan Cao*, Shaina Huang, Angika Basant, Miroslav Mladenov and Michael Way*
EMBO reports 25:3221-3239 2024. * co-corresponding
Regeneration of actin filament branches from the same Arp2/3 complex.
Foad Ghasemi, LuYan Cao, Miroslav Mladenov, Bérengère Guichard, Michael Way, Antoine Jégou*, and Guillaume Romet-Lemonne*. Science Advances. 10(4):eadj7681. 2024 * co-corresponding
Cortactin stabilizes actin branches by bridging activated Arp2/3 to its nucleated actin filament.
Tianyang Liu, Luyan Cao, Miroslav Mladenov, Antoine Jegou, Michael Way* and CarolynA. Moores*.
Nature Structural & Molecular Biology 5:801-809. 2024. * co-corresponding
Palisade structure in intact vaccinia virions.
Miguel Hernandez-Gonzalez#, Thomas Calcraft#, Andrea Nans, Peter B Rosenthal* and Michael Way*.
mBio 15:e03134-23. 2024 # co-first author * co-corresponding
The level of Nck rather than N-WASP determines the rate of actin-based motility of Vaccinia.
Angika Basant and Michael Way. Microbiology Spectrum 19:e0152923. 2023
ARPC5 deficiency leads to severe early onset systemic inflammation and mortality.
Elena Sindram#, Andrés Caballero-Oteyza#, Naoko Kogata#, Shaina Huang, Zahra Alizadeh, Laura Gamez, Mohammad Reza Fazlollhi, Xiao Peng, Bodo Grimbacher, Michael Way* and Michele Proietti*. Disease Models & Mechanisms 10.1242/dmm.050145. 2023 # co-first author * co-corresponding
ARPC5 Isoforms and Their Regulation by Calcium-Calmodulin-N-WASP Drive Distinct Arp2/3-dependent Actin Remodeling Events in CD4 T Cells. Lopamudra Sadhu, Nikolaos Tsopoulidis, Md Hasanuzzaman, Vibor Laketa, Michael Way and Oliver T. Fackler. Elife 12:e82450. 2023
Biomimetic actin cortices shape cell-sized lipid vesicles.
Lucia Baldauf, Felix Frey, Marcos Arribas Perez, Miroslav Mladenov, Michael Way*, Timon Idema*, and Gijsje H Koenderink*. 2023 BioRxiv. https://doi.org/10.1101/2023.01.15.524117
Regulation of branched versus linear Arp2/3-generated actin filaments.
Luyan Cao, Foad Ghasemi, Michael Way, Antoine Jégou and Guillaume Romet-Lemonne. EMBO J. e113008. 2023
A succession of two viral lattices drives vaccinia virus assembly.
Miguel Hernandez-Gonzalez, Thomas Calcraft, Andrea Nans, Peter B Rosenthal and Michael Way.
PLoS Biol 21(3): e3002005. 2023
Kinesin-1 transports morphologically distinct intracellular virions during vaccinia infection.
Amadeus Xu, Angika Basant, Sibylle Schleich, Timothy P. Newsome and Michael Way.
Journal Cell Science 136: jcs260175. 2023.
The Relative Binding Position of Nck and Grb2 Adaptors Dramatically Impacts Actin-Based Motility of Vaccinia Virus. Angika Basant and Michael Way. Elife 11:e74655. 2022
MICAL2 enhances branched actin network disassembly by oxidizing Arp3B-containing Arp2/3 complexes.
Chiara Galloni#, Davide Carra#, Jasmine V. G. Abella, Svend Kjaer, Pavithra Singaravelu David J. Barry, Naoko Kogata, Christophe Guérin, Laurent Blanchoin and Michael Way. J. Cell Biol. 220:e202102043. 2021 # co-first author
Cryo-EM of human Arp2/3 complexes provides structural insights into actin nucleation modulation by ARPC5 isoforms. Ottilie von Loeffelholz, Andrew Purkiss, Luyan Cao, Svend Kjaer, Naoko Kogata, Guillaume Romet-Lemonne, Michael Way* and Carolyn A. Moores* Biology Open 9:bio.054304. 2020 * co-corresponding
Lamellipodin tunes cell migration by stabilizing protrusions and promoting adhesion formation.
Georgi Dimchev, Behnam Amiri, Ashley C. Humphries, Matthias Schaks, Vanessa Dimchev, Theresia E.B. Stradal, Jan Faix, Matthias Krause, Michael Way, Martin Falcke and Klemens Rottner. J. Cell Science. 133: jcs239020. 2020